The design of trials for prevention of IDDM.
نویسندگان
چکیده
Several large clinical trials for the prevention of IDDM in islet cell antibody positive first-degree relatives are planned or underway. The design of these trials rests in part on assumptions about the natural history of autoimmunity during the prediabetic period and on the likely effectiveness of the intervention being tested. At this time, most of the factors that influence the required sample size can only be roughly estimated.
منابع مشابه
The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review
Background: Aloe vera is an herbaceous and perennial plant that belongs to the Liliaceae family and used for many medicinal purposes. The present study aimed to systematically review clinical trials regarding the effect of Aloe vera on the prevention and healing of skin wounds.Methods: To identify all related published studies, we searched SID, IRANDOC, Google Scholar, PubMed, MEDLINE, Scopus, ...
متن کاملHypercalciuria, Hyperphosphaturia and Growth Retardation in Children with Diabetes Mellitus
Background: Previous studies have demonstrated that patients with insulin-dependent diabetes mellitus (IDDM) have a high prevalence of osteopenia. Hypercalciuria has also been well documented in human diabetes and many children with insulin-dependent diabetes mellitus have short stature. Objective: To investigate the relationship of hypercalciuria and hyperphosphaturia with growth retardation ...
متن کاملMicroalbuminuria, cardiovascular risk factors, and secondary prevention of non-insulin-dependent diabetes.
Letters to the Editor Microalbuminuria, cardiovas-cular risk factors, and secondary prevention of non-insulin-dependent diabetes Sir, We have read with interest the recent leading article by Drs Dornhorst and Merrin' about the primary, secondary and tertiary prevention of non-insulin-dependent diabetes (NIDDM). Among the possible modes of secondary prevention, the clinical significance of micro...
متن کاملO-18: Framework of Informed Consent and Ethical Codes for Clinical Trials Especially Designed for Assisted Reproduction
Background Clinical trials are known as the most valid medical research. It is able to promote medical evidences on prevention, diagnosis, screening, treatment, and quality of life because in this type of study, an intervention is intentionally performed on subjects. Therefore, it encompasses ethical concerns and considerations, especially when human subjects are studied. In other words, clinic...
متن کاملEvaluation of Clinical Trials
In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Diabetes
دوره 42 7 شماره
صفحات -
تاریخ انتشار 1993